In vitro Cultivation and Visualization of Malaria Liver Stages in Primary Simian Hepatocytes

Autor Gupta, Devendra Kumar, Diagana, Thierry
Vydáno v Bio Protoc (2020)

The Spiroindolone KAE609 Does Not Induce Dormant Ring Stages in Plasmodium falciparum Parasites

Autor Chavchich, Marina, Van Breda, Karin, Rowcliffe, Kerryn, Diagana, Thierry T., Edstein, Michael D.
Vydáno v Antimicrob Agents Chemother (2016)

A First-in-Human Randomized, Double-Blind, Placebo-Controlled, Single- and Multiple-Ascending Oral Dose Study of Novel Imidazolopiperazine KAF156 To Assess Its Safety, Tolerability...

Autor Leong, F. Joel, Zhao, Rong, Zeng, Shuqi, Magnusson, Baldur, Diagana, Thierry T., Pertel, Peter
Vydáno v Antimicrob Agents Chemother (2014)

A first-in-human randomized, double-blind, placebo-controlled, single- and multiple-ascending oral dose study of novel spiroindolone KAE609, to assess the safety, tolerability and...

Autor Leong, Joel, Li, Ruobing, Jain, Jay Prakash, Lefèvre, Gilbert, Magnusson, Baldur, Diagana, Thierry, Pertel, Peter
Vydáno 2014

Mutation of Drosophila homer Disrupts Control of Locomotor Activity and Behavioral Plasticity

Autor Diagana, Thierry T., Thomas, Ulrich, Prokopenko, Sergei N., Xiao, Bo, Worley, Paul F., Thomas, John B.
Vydáno v J Neurosci (2002)

A First-in-Human Randomized, Double-Blind, Placebo-Controlled, Single- and Multiple-Ascending Oral Dose Study of Novel Antimalarial Spiroindolone KAE609 (Cipargamin) To Assess Its...

Autor Leong, F. Joel, Li, Ruobing, Jain, Jay Prakash, Lefèvre, Gilbert, Magnusson, Baldur, Diagana, Thierry T., Pertel, Peter
Vydáno 2014

Global Phenotypic Screening for Antimalarials

Autor Guiguemde, W. Armand, Shelat, Anang A., Garcia-Bustos, Jose F., Diagana, Thierry, Gamo, Francisco-Javier, Guy, R. Kiplin
Vydáno 2012

Na(+) Regulation in the Malaria Parasite Plasmodiumfalciparum Involves the Cation ATPase PfATP4 and Is a Target of the Spiroindolone Antimalarials

Autor Spillman, Natalie J., Allen, Richard J.W., McNamara, Case W., Yeung, Bryan K.S., Winzeler, Elizabeth A., Diagana, Thierry T., Kirk, Kiaran
Vydáno 2013

Use-case scenarios for an anti-Cryptosporidium therapeutic

Autor Ashigbie, Paul G., Shepherd, Susan, Steiner, Kevin L., Amadi, Beatrice, Aziz, Natasha, Manjunatha, Ujjini H., Spector, Jonathan M., Diagana, Thierry T., Kelly, Paul
Vydáno v PLoS Negl Trop Dis (2021)

Pharmacokinetic-Pharmacodynamic Analysis of Spiroindolone Analogs and KAE609 in a Murine Malaria Model

Autor Lakshminarayana, Suresh B., Freymond, Céline, Fischli, Christoph, Yu, Jing, Weber, Sebastian, Goh, Anne, Yeung, Bryan K. S., Ho, Paul C., Dartois, Véronique, Diagana, Thierry T., Rottmann, Matthias, Blasco, Francesca
Vydáno v Antimicrob Agents Chemother (2015)

Imidazolopiperazines Kill both Rings and Dormant Rings in Wild-Type and K13 Artemisinin-Resistant Plasmodium falciparum In Vitro

Autor Dembele, Laurent, Gupta, Devendra Kumar, Lim, Michelle Yi-Xiu, Ang, Xiaoman, Selva, Jeremy J., Chotivanich, Kesinee, Nguon, Chea, Dondorp, Arjen M., Bonamy, Ghislain M. C., Diagana, Thierry T., Bifani, Pablo
Vydáno v Antimicrob Agents Chemother (2018)

Spiroindolone KAE609 for Falciparum and Vivax Malaria

Autor White, Nicholas J., Pukrittayakamee, Sasithon, Phyo, Aung Pyae, Rueangweerayut, Ronnatrai, Nosten, François, Jittamala, Podjanee, Jeeyapant, Atthanee, Jain, Jay Prakash, Lefèvre, Gilbert, Li, Ruobing, Magnusson, Baldur, Diagana, Thierry T., Leong, F. Joel
Vydáno 2014

Targeting the ERAD pathway via inhibition of signal peptide peptidase for antiparasitic therapeutic design

Autor Harbut, Michael B., Patel, Bhumit A., Yeung, Bryan K. S., McNamara, Case W., Bright, A. Taylor, Ballard, Jaime, Supek, Frantisek, Golde, Todd E., Winzeler, Elizabeth A., Diagana, Thierry T., Greenbaum, Doron C.
Vydáno 2012

Anti-Trypanosomal Proteasome Inhibitors Cure Hemolymphatic and Meningoencephalic Murine Infection Models of African Trypanosomiasis

Autor Rao, Srinivasa P S, Lakshminarayana, Suresh B, Jiricek, Jan, Kaiser, Marcel, Ritchie, Ryan, Myburgh, Elmarie, Supek, Frantisek, Tuntland, Tove, Nagle, Advait, Molteni, Valentina, Mäser, Pascal, Mottram, Jeremy C, Barrett, Michael P, Diagana, Thierry T
Vydáno v Trop Med Infect Dis (2020)

Opportunities and Challenges in Developing a Cryptosporidium Controlled Human Infection Model for Testing Antiparasitic Agents

Autor Jumani, Rajiv S., Blais, Johanne, Tillmann, Hanns-Christian, Segal, Florencia, Wetty, Dean, Ostermeier, Christian, Nuber, Natko, Lakshman, Jay, Aziz, Natasha, Chandra, Richa, Chen, Wilbur H., Chappell, Cynthia L., Diagana, Thierry T., Manjunatha, Ujjini H.
Vydáno v ACS Infect Dis (2021)

PI4 Kinase Is a Prophylactic but Not Radical Curative Target in Plasmodium vivax-Type Malaria Parasites

Autor Zeeman, Anne-Marie, Lakshminarayana, Suresh B., van der Werff, Nicole, Klooster, Els J., Voorberg-van der Wel, Annemarie, Kondreddi, Ravinder R., Bodenreider, Christophe, Simon, Oliver, Sauerwein, Robert, Yeung, Bryan K. S., Diagana, Thierry T., Kocken, Clemens H. M.
Vydáno v Antimicrob Agents Chemother (2016)

A dual fluorescent Plasmodium cynomolgi reporter line reveals in vitro malaria hypnozoite reactivation

Autor Voorberg-van der Wel, Annemarie M., Zeeman, Anne-Marie, Nieuwenhuis, Ivonne G., van der Werff, Nicole M., Klooster, Els J., Klop, Onny, Vermaat, Lars C., Kumar Gupta, Devendra, Dembele, Laurent, Diagana, Thierry T., Kocken, Clemens H. M.
Vydáno v Commun Biol (2020)

The Plasmodium liver-specific protein 2 (LISP2) is an early marker of liver stage development

Autor Gupta, Devendra Kumar, Dembele, Laurent, Voorberg-van der Wel, Annemarie, Roma, Guglielmo, Yip, Andy, Chuenchob, Vorada, Kangwanrangsan, Niwat, Ishino, Tomoko, Vaughan, Ashley M, Kappe, Stefan H, Flannery, Erika L, Sattabongkot, Jetsumon, Mikolajczak, Sebastian, Bifani, Pablo, Kocken, Clemens HM, Diagana, Thierry Tidiane
Vydáno v eLife (2019)

Antimalarial Activity of KAF156 in Falciparum and Vivax Malaria

Autor White, Nicholas J., Duong, Tran T., Uthaisin, Chirapong, Nosten, François, Phyo, Aung P., Hanboonkunupakarn, Borimas, Pukrittayakamee, Sasithon, Jittamala, Podjanee, Chuthasmit, Kittiphum, Cheung, Ming S., Feng, Yiyan, Li, Ruobing, Magnusson, Baldur, Sultan, Marc, Wieser, Daniela, Xun, Xiaolei, Zhao, Rong, Diagana, Thierry T., Pertel, Peter, Leong, F. Joel
Vydáno v N Engl J Med (2016)

Preclinical Evaluation of the Antifolate QN254, 5-Chloro- N′6′-(2,5-Dimethoxy-Benzyl)-Quinazoline-2,4,6-Triamine, as an Antimalarial Drug Candidate

Autor Nzila, Alexis, Rottmann, Matthias, Chitnumsub, Penchit, Kiara, Stevens M., Kamchonwongpaisan, Sumalee, Maneeruttanarungroj, Cherdsak, Taweechai, Supannee, Yeung, Bryan K. S., Goh, Anne, Lakshminarayana, Suresh B., Zou, Bin, Wong, Josephine, Ma, Ngai Ling, Weaver, Margaret, Keller, Thomas H., Dartois, Veronique, Wittlin, Sergio, Brun, Reto, Yuthavong, Yongyuth, Diagana, Thierry T.
Vydáno 2010