PI4 Kinase Is a Prophylactic but Not Radical Curative Target in Plasmodium vivax-Type Malaria Parasites

Two Plasmodium PI4 kinase (PI4K) inhibitors, KDU691 and LMV599, were selected for in vivo testing as causal prophylactic and radical-cure agents for Plasmodium cynomolgi sporozoite-infected rhesus macaques, based on their in vitro activity against liver stages. Animals were infected with P. cynomolg...

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Detalhes bibliográficos
Publicado no:Antimicrob Agents Chemother
Main Authors: Zeeman, Anne-Marie, Lakshminarayana, Suresh B., van der Werff, Nicole, Klooster, Els J., Voorberg-van der Wel, Annemarie, Kondreddi, Ravinder R., Bodenreider, Christophe, Simon, Oliver, Sauerwein, Robert, Yeung, Bryan K. S., Diagana, Thierry T., Kocken, Clemens H. M.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2016
Assuntos:
Clinical Therapeutics
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4862498/
https://ncbi.nlm.nih.gov/pubmed/26926645
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.03080-15
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