Antimalarial Activity of KAF156 in Falciparum and Vivax Malaria

BACKGROUND: KAF156 belongs to a new class of antimalarial agents (imidazolopiperazines), with activity against asexual and sexual blood stages and the preerythrocytic liver stages of malarial parasites. METHODS: We conducted a phase 2, open-label, two-part study at five centers in Thailand and Vietn...

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Published in:N Engl J Med
Main Authors: White, Nicholas J., Duong, Tran T., Uthaisin, Chirapong, Nosten, François, Phyo, Aung P., Hanboonkunupakarn, Borimas, Pukrittayakamee, Sasithon, Jittamala, Podjanee, Chuthasmit, Kittiphum, Cheung, Ming S., Feng, Yiyan, Li, Ruobing, Magnusson, Baldur, Sultan, Marc, Wieser, Daniela, Xun, Xiaolei, Zhao, Rong, Diagana, Thierry T., Pertel, Peter, Leong, F. Joel
Format: Artigo
Language:Inglês
Published: 2016
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5142602/
https://ncbi.nlm.nih.gov/pubmed/27653565
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1056/NEJMoa1602250
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