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Antimalarial activity of artefenomel (OZ439), a novel synthetic antimalarial endoperoxide, in patients with Plasmodium falciparum and Plasmodium vivax malaria: an open-label phase 2 trial

BACKGROUND: Artefenomel (OZ439) is a novel synthetic trioxolane with improved pharmacokinetic properties compared with other antimalarial drugs with the artemisinin pharmacophore. Artefenomel has been generally well tolerated in volunteers at doses up to 1600 mg and is being developed as a partner d...

תיאור מלא

שמור ב:
מידע ביבליוגרפי
הוצא לאור ב:Lancet Infect Dis
Main Authors: Phyo, Aung Pyae, Jittamala, Podjanee, Nosten, François H, Pukrittayakamee, Sasithon, Imwong, Mallika, White, Nicholas J, Duparc, Stephan, Macintyre, Fiona, Baker, Mark, Möhrle, Jörg J
פורמט: Artigo
שפה:Inglês
יצא לאור: Elsevier Science ;, The Lancet Pub. Group 2016
נושאים:
גישה מקוונת:https://ncbi.nlm.nih.gov/pmc/articles/PMC4700386/
https://ncbi.nlm.nih.gov/pubmed/26448141
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/S1473-3099(15)00320-5
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