Antimalarial activity of artefenomel (OZ439), a novel synthetic antimalarial endoperoxide, in patients with Plasmodium falciparum and Plasmodium vivax malaria: an open-label phase 2 trial

BACKGROUND: Artefenomel (OZ439) is a novel synthetic trioxolane with improved pharmacokinetic properties compared with other antimalarial drugs with the artemisinin pharmacophore. Artefenomel has been generally well tolerated in volunteers at doses up to 1600 mg and is being developed as a partner d...

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Detaylı Bibliyografya
Yayımlandı:Lancet Infect Dis
Asıl Yazarlar: Phyo, Aung Pyae, Jittamala, Podjanee, Nosten, François H, Pukrittayakamee, Sasithon, Imwong, Mallika, White, Nicholas J, Duparc, Stephan, Macintyre, Fiona, Baker, Mark, Möhrle, Jörg J
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: Elsevier Science ;, The Lancet Pub. Group 2016
Konular:
Articles
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC4700386/
https://ncbi.nlm.nih.gov/pubmed/26448141
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/S1473-3099(15)00320-5
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