Efficacy of OZ439 (artefenomel) against early Plasmodium falciparum blood-stage malaria infection in healthy volunteers

OBJECTIVES: OZ439, or artefenomel, is an investigational synthetic ozonide antimalarial with similar potency, but a significantly improved pharmacokinetic profile, compared with artemisinins. We wished to measure key pharmacokinetic and pharmacodynamic parameters and the pharmacokinetic/pharmacodyna...

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Dettagli Bibliografici
Pubblicato in:J Antimicrob Chemother
Autori principali: McCarthy, James S., Baker, Mark, O'Rourke, Peter, Marquart, Louise, Griffin, Paul, Hooft van Huijsduijnen, Rob, Möhrle, Jörg J.
Natura: Artigo
Lingua:Inglês
Pubblicazione: Oxford University Press 2016
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Original Research
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4992851/
https://ncbi.nlm.nih.gov/pubmed/27272721
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/jac/dkw174
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