A Single-Dose Combination Study with the Experimental Antimalarials Artefenomel and DSM265 To Determine Safety and Antimalarial Activity against Blood-Stage Plasmodium falciparum in Healthy Volunteers

Artefenomel and DSM265 are two new compounds that have been shown to be well tolerated and effective when administered as monotherapy malaria treatment. This study aimed to determine the safety, pharmacokinetics, and pharmacodynamics of artefenomel and DSM265 administered in combination to healthy s...

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Shranjeno v:
Bibliografske podrobnosti
izdano v:Antimicrob Agents Chemother
Main Authors: McCarthy, James S., Rückle, Thomas, Elliott, Suzanne L., Ballard, Emma, Collins, Katharine A., Marquart, Louise, Griffin, Paul, Chalon, Stephan, Möhrle, Jörg J.
Format: Artigo
Jezik:Inglês
Izdano: American Society for Microbiology 2019
Teme:
Clinical Therapeutics
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC7187626/
https://ncbi.nlm.nih.gov/pubmed/31685476
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.01371-19
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