Antimalarial Activity of KAF156 in Falciparum and Vivax Malaria

BACKGROUND: KAF156 belongs to a new class of antimalarial agents (imidazolopiperazines), with activity against asexual and sexual blood stages and the preerythrocytic liver stages of malarial parasites. METHODS: We conducted a phase 2, open-label, two-part study at five centers in Thailand and Vietn...

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Vydáno v:N Engl J Med
Hlavní autoři: White, Nicholas J., Duong, Tran T., Uthaisin, Chirapong, Nosten, François, Phyo, Aung P., Hanboonkunupakarn, Borimas, Pukrittayakamee, Sasithon, Jittamala, Podjanee, Chuthasmit, Kittiphum, Cheung, Ming S., Feng, Yiyan, Li, Ruobing, Magnusson, Baldur, Sultan, Marc, Wieser, Daniela, Xun, Xiaolei, Zhao, Rong, Diagana, Thierry T., Pertel, Peter, Leong, F. Joel
Médium: Artigo
Jazyk:Inglês
Vydáno: 2016
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5142602/
https://ncbi.nlm.nih.gov/pubmed/27653565
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1056/NEJMoa1602250
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