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Na(+) Regulation in the Malaria Parasite Plasmodiumfalciparum Involves the Cation ATPase PfATP4 and Is a Target of the Spiroindolone Antimalarials

The malaria parasite Plasmodium falciparum establishes in the host erythrocyte plasma membrane new permeability pathways that mediate nutrient uptake into the infected cell. These pathways simultaneously allow Na(+) influx, causing [Na(+)] in the infected erythrocyte cytosol to increase to high leve...

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Autors principals: Spillman, Natalie J., Allen, Richard J.W., McNamara, Case W., Yeung, Bryan K.S., Winzeler, Elizabeth A., Diagana, Thierry T., Kirk, Kiaran
Format: Artigo
Idioma:Inglês
Publicat: Cell Press 2013
Matèries:
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3574224/
https://ncbi.nlm.nih.gov/pubmed/23414762
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.chom.2012.12.006
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