Discovery of Dengue Virus NS4B Inhibitors

The four serotypes of dengue virus (DENV-1 to -4) represent the most prevalent mosquito-borne viral pathogens in humans. No clinically approved vaccine or antiviral is currently available for DENV. Here we report a spiropyrazolopyridone compound that potently inhibits DENV both in vitro and in vivo....

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:J Virol
Prif Awduron: Wang, Qing-Yin, Dong, Hongping, Zou, Bin, Karuna, Ratna, Wan, Kah Fei, Zou, Jing, Susila, Agatha, Yip, Andy, Shan, Chao, Yeo, Kim Long, Xu, Haoying, Ding, Mei, Chan, Wai Ling, Gu, Feng, Seah, Peck Gee, Liu, Wei, Lakshminarayana, Suresh B., Kang, CongBao, Lescar, Julien, Blasco, Francesca, Smith, Paul W., Shi, Pei-Yong
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: American Society for Microbiology 2015
Pynciau:
Vaccines and Antiviral Agents
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC4524232/
https://ncbi.nlm.nih.gov/pubmed/26018165
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.00855-15
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