Lead Optimization of Spiropyrazolopyridones: A New and Potent Class of Dengue Virus Inhibitors

[Image: see text] Spiropyrazolopyridone 1 was identified, as a novel dengue virus (DENV) inhibitor, from a DENV serotype 2 (DENV-2) high-throughput phenotypic screen. As a general trend within this chemical class, chiral resolution of the racemate revealed that R enantiomer was significantly more po...

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Pubblicato in:ACS Med Chem Lett
Autori principali: Zou, Bin, Chan, Wai Ling, Ding, Mei, Leong, Seh Yong, Nilar, Shahul, Seah, Peck Gee, Liu, Wei, Karuna, Ratna, Blasco, Francesca, Yip, Andy, Chao, Alex, Susila, Agatha, Dong, Hongping, Wang, Qing Yin, Xu, Hao Ying, Chan, Katherine, Wan, Kah Fei, Gu, Feng, Diagana, Thierry T., Wagner, Trixie, Dix, Ina, Shi, Pei-Yong, Smith, Paul W.
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Chemical Society 2015
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4360157/
https://ncbi.nlm.nih.gov/pubmed/25878766
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ml500521r
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