A Conserved Pocket in the Dengue Virus Polymerase Identified through Fragment-based Screening

Por Noble, Christian G., Lim, Siew Pheng, Arora, Rishi, Yokokawa, Fumiaki, Nilar, Shahul, Seh, Cheah Chen, Wright, S. Kirk, Benson, Timothy E., Smith, Paul W., Shi, Pei-Yong
Publicado no J Biol Chem (2016)

Inhibition of Dengue Virus Polymerase by Blocking of the RNA Tunnel

Por Niyomrattanakit, Pornwaratt, Chen, Yen-Liang, Dong, Hongping, Yin, Zheng, Qing, Min, Glickman, J. Frasier, Lin, Kai, Mueller, Dieter, Voshol, Hans, Lim, Joanne Y. H., Nilar, Shahul, Keller, Thomas H., Shi, Pei-Yong
Publicado em 2010

A Translation Inhibitor That Suppresses Dengue Virus In Vitro and In Vivo

Por Wang, Qing-Yin, Kondreddi, Ravinder Reddy, Xie, Xuping, Rao, Ranga, Nilar, Shahul, Xu, Hao Ying, Qing, Min, Chang, David, Dong, Hongping, Yokokawa, Fumiaki, Lakshminarayana, Suresh B., Goh, Anne, Schul, Wouter, Kramer, Laura, Keller, Thomas H., Shi, Pei-Yong
Publicado em 2011

Potent Allosteric Dengue Virus NS5 Polymerase Inhibitors: Mechanism of Action and Resistance Profiling

Por Lim, Siew Pheng, Noble, Christian Guy, Seh, Cheah Chen, Soh, Tingjin Sherryl, El Sahili, Abbas, Chan, Grace Kar Yarn, Lescar, Julien, Arora, Rishi, Benson, Timothy, Nilar, Shahul, Manjunatha, Ujjini, Wan, Kah Fei, Dong, Hongping, Xie, Xuping, Shi, Pei-Yong, Yokokawa, Fumiaki
Publicado no PLoS Pathog (2016)

Inhibition of Dengue Virus through Suppression of Host Pyrimidine Biosynthesis

Por Wang, Qing-Yin, Bushell, Simon, Qing, Min, Xu, Hao Ying, Bonavia, Aurelio, Nunes, Sandra, Zhou, Jing, Poh, Mee Kian, Florez de Sessions, Paola, Niyomrattanakit, Pornwaratt, Dong, Hongping, Hoffmaster, Keith, Goh, Anne, Nilar, Shahul, Schul, Wouter, Jones, Susan, Kramer, Laura, Compton, Teresa, Shi, Pei-Yong
Publicado em 2011

Small Molecule Inhibitors That Selectively Block Dengue Virus Methyltransferase

Por Lim, Siew Pheng, Sonntag, Louis Sebastian, Noble, Christian, Nilar, Shahul H., Ng, Ru Hui, Zou, Gang, Monaghan, Paul, Chung, Ka Yan, Dong, Hongping, Liu, Boping, Bodenreider, Christophe, Lee, Gladys, Ding, Mei, Chan, Wai Ling, Wang, Gang, Jian, Yap Li, Chao, Alexander Theodore, Lescar, Julien, Yin, Zheng, Vedananda, T. R., Keller, Thomas H., Shi, Pei-Yong
Publicado em 2011

Lead Optimization of Spiropyrazolopyridones: A New and Potent Class of Dengue Virus Inhibitors

Por Zou, Bin, Chan, Wai Ling, Ding, Mei, Leong, Seh Yong, Nilar, Shahul, Seah, Peck Gee, Liu, Wei, Karuna, Ratna, Blasco, Francesca, Yip, Andy, Chao, Alex, Susila, Agatha, Dong, Hongping, Wang, Qing Yin, Xu, Hao Ying, Chan, Katherine, Wan, Kah Fei, Gu, Feng, Diagana, Thierry T., Wagner, Trixie, Dix, Ina, Shi, Pei-Yong, Smith, Paul W.
Publicado no ACS Med Chem Lett (2015)