Inhibition of Dengue Virus through Suppression of Host Pyrimidine Biosynthesis

Viral replication relies on the host to supply nucleosides. Host enzymes involved in nucleoside biosynthesis are potential targets for antiviral development. Ribavirin (a known antiviral drug) is such an inhibitor that suppresses guanine biosynthesis; depletion of the intracellular GTP pool was show...

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Detalhes bibliográficos
Main Authors: Wang, Qing-Yin, Bushell, Simon, Qing, Min, Xu, Hao Ying, Bonavia, Aurelio, Nunes, Sandra, Zhou, Jing, Poh, Mee Kian, Florez de Sessions, Paola, Niyomrattanakit, Pornwaratt, Dong, Hongping, Hoffmaster, Keith, Goh, Anne, Nilar, Shahul, Schul, Wouter, Jones, Susan, Kramer, Laura, Compton, Teresa, Shi, Pei-Yong
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2011
Assuntos:
Vaccines and Antiviral Agents
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3126545/
https://ncbi.nlm.nih.gov/pubmed/21507975
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.02510-10
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