Inhibition of Dengue Virus through Suppression of Host Pyrimidine Biosynthesis

Viral replication relies on the host to supply nucleosides. Host enzymes involved in nucleoside biosynthesis are potential targets for antiviral development. Ribavirin (a known antiviral drug) is such an inhibitor that suppresses guanine biosynthesis; depletion of the intracellular GTP pool was show...

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Bibliographische Detailangaben
Hauptverfasser: Wang, Qing-Yin, Bushell, Simon, Qing, Min, Xu, Hao Ying, Bonavia, Aurelio, Nunes, Sandra, Zhou, Jing, Poh, Mee Kian, Florez de Sessions, Paola, Niyomrattanakit, Pornwaratt, Dong, Hongping, Hoffmaster, Keith, Goh, Anne, Nilar, Shahul, Schul, Wouter, Jones, Susan, Kramer, Laura, Compton, Teresa, Shi, Pei-Yong
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Microbiology 2011
Schlagworte:
Vaccines and Antiviral Agents
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3126545/
https://ncbi.nlm.nih.gov/pubmed/21507975
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.02510-10
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