Inhibition of Dengue Virus Polymerase by Blocking of the RNA Tunnel

Dengue virus (DENV) is the most prevalent mosquito-borne viral pathogen in humans. Neither vaccine nor antiviral therapy is currently available for DENV. We report here that N-sulfonylanthranilic acid derivatives are allosteric inhibitors of DENV RNA-dependent RNA polymerase (RdRp). The inhibitor wa...

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Detalhes bibliográficos
Main Authors: Niyomrattanakit, Pornwaratt, Chen, Yen-Liang, Dong, Hongping, Yin, Zheng, Qing, Min, Glickman, J. Frasier, Lin, Kai, Mueller, Dieter, Voshol, Hans, Lim, Joanne Y. H., Nilar, Shahul, Keller, Thomas H., Shi, Pei-Yong
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology (ASM) 2010
Assuntos:
Genome Replication and Regulation of Viral Gene Expression
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2876596/
https://ncbi.nlm.nih.gov/pubmed/20237086
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.02451-09
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