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Characterization of Dengue Virus Resistance to Brequinar in Cell Culture
Brequinar is an inhibitor of dihydroorotate dehydrogenase, an enzyme that is required for de novo pyrimidine biosynthesis. Here we report that brequinar has activity against a broad spectrum of viruses. The compound not only inhibits flaviviruses (dengue virus, West Nile virus, yellow fever virus, a...
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| Main Authors: | , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
American Society for Microbiology (ASM)
2010
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2934995/ https://ncbi.nlm.nih.gov/pubmed/20606073 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.00561-10 |
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