A Translation Inhibitor That Suppresses Dengue Virus In Vitro and In Vivo

We describe a novel translation inhibitor that has anti-dengue virus (DENV) activity in vitro and in vivo. The inhibitor was identified through a high-throughput screening using a DENV infection assay. The compound contains a benzomorphan core structure. Mode-of-action analysis indicated that the co...

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Detalhes bibliográficos
Main Authors: Wang, Qing-Yin, Kondreddi, Ravinder Reddy, Xie, Xuping, Rao, Ranga, Nilar, Shahul, Xu, Hao Ying, Qing, Min, Chang, David, Dong, Hongping, Yokokawa, Fumiaki, Lakshminarayana, Suresh B., Goh, Anne, Schul, Wouter, Kramer, Laura, Keller, Thomas H., Shi, Pei-Yong
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2011
Assuntos:
Antiviral Agents
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3165312/
https://ncbi.nlm.nih.gov/pubmed/21730119
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.00620-11
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