Inhibition of Dengue Virus RNA Synthesis by an Adenosine Nucleoside

We recently reported that (2R,3R,4R,5R)-2-(4-amino-pyrrolo[2,3-d]pyrimidin-7-yl)-3-ethynyl-5-hydroxy-methyl-tetrahydro-furan-3,4-diol is a potent inhibitor of dengue virus (DENV), with 50% effective concentration (EC(50)) and cytotoxic concentration (CC(50)) values of 0.7 μM and >100 μM, respecti...

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Detalhes bibliográficos
Main Authors: Chen, Yen-Liang, Yin, Zheng, Duraiswamy, Jeyaraj, Schul, Wouter, Lim, Chin Chin, Liu, Boping, Xu, Hao Ying, Qing, Min, Yip, Andy, Wang, Gang, Chan, Wai Ling, Tan, Hui Pen, Lo, Melissa, Liung, Sarah, Kondreddi, Ravinder Reddy, Rao, Ranga, Gu, Helen, He, Handan, Keller, Thomas H., Shi, Pei-Yong
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology (ASM) 2010
Assuntos:
Antiviral Agents
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2897296/
https://ncbi.nlm.nih.gov/pubmed/20457821
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.00140-10
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