Inhibition of Dengue Virus RNA Synthesis by an Adenosine Nucleoside

We recently reported that (2R,3R,4R,5R)-2-(4-amino-pyrrolo[2,3-d]pyrimidin-7-yl)-3-ethynyl-5-hydroxy-methyl-tetrahydro-furan-3,4-diol is a potent inhibitor of dengue virus (DENV), with 50% effective concentration (EC(50)) and cytotoxic concentration (CC(50)) values of 0.7 μM and >100 μM, respecti...

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Dades bibliogràfiques
Autors principals: Chen, Yen-Liang, Yin, Zheng, Duraiswamy, Jeyaraj, Schul, Wouter, Lim, Chin Chin, Liu, Boping, Xu, Hao Ying, Qing, Min, Yip, Andy, Wang, Gang, Chan, Wai Ling, Tan, Hui Pen, Lo, Melissa, Liung, Sarah, Kondreddi, Ravinder Reddy, Rao, Ranga, Gu, Helen, He, Handan, Keller, Thomas H., Shi, Pei-Yong
Format: Artigo
Idioma:Inglês
Publicat: American Society for Microbiology (ASM) 2010
Matèries:
Antiviral Agents
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2897296/
https://ncbi.nlm.nih.gov/pubmed/20457821
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.00140-10
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