Inhibition of Dengue Virus RNA Synthesis by an Adenosine Nucleoside

We recently reported that (2R,3R,4R,5R)-2-(4-amino-pyrrolo[2,3-d]pyrimidin-7-yl)-3-ethynyl-5-hydroxy-methyl-tetrahydro-furan-3,4-diol is a potent inhibitor of dengue virus (DENV), with 50% effective concentration (EC(50)) and cytotoxic concentration (CC(50)) values of 0.7 μM and >100 μM, respecti...

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מידע ביבליוגרפי
Main Authors: Chen, Yen-Liang, Yin, Zheng, Duraiswamy, Jeyaraj, Schul, Wouter, Lim, Chin Chin, Liu, Boping, Xu, Hao Ying, Qing, Min, Yip, Andy, Wang, Gang, Chan, Wai Ling, Tan, Hui Pen, Lo, Melissa, Liung, Sarah, Kondreddi, Ravinder Reddy, Rao, Ranga, Gu, Helen, He, Handan, Keller, Thomas H., Shi, Pei-Yong
פורמט: Artigo
שפה:Inglês
יצא לאור: American Society for Microbiology (ASM) 2010
נושאים:
Antiviral Agents
גישה מקוונת:https://ncbi.nlm.nih.gov/pmc/articles/PMC2897296/
https://ncbi.nlm.nih.gov/pubmed/20457821
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.00140-10
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