Discovery of Dengue Virus NS4B Inhibitors

The four serotypes of dengue virus (DENV-1 to -4) represent the most prevalent mosquito-borne viral pathogens in humans. No clinically approved vaccine or antiviral is currently available for DENV. Here we report a spiropyrazolopyridone compound that potently inhibits DENV both in vitro and in vivo....

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Detalhes bibliográficos
Publicado no:J Virol
Main Authors: Wang, Qing-Yin, Dong, Hongping, Zou, Bin, Karuna, Ratna, Wan, Kah Fei, Zou, Jing, Susila, Agatha, Yip, Andy, Shan, Chao, Yeo, Kim Long, Xu, Haoying, Ding, Mei, Chan, Wai Ling, Gu, Feng, Seah, Peck Gee, Liu, Wei, Lakshminarayana, Suresh B., Kang, CongBao, Lescar, Julien, Blasco, Francesca, Smith, Paul W., Shi, Pei-Yong
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2015
Assuntos:
Vaccines and Antiviral Agents
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4524232/
https://ncbi.nlm.nih.gov/pubmed/26018165
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.00855-15
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