Mutations in Genes for the F(420) Biosynthetic Pathway and a Nitroreductase Enzyme Are the Primary Resistance Determinants in Spontaneous In Vitro-Selected PA-824-Resistant Mutants of Mycobacterium tuberculosis

Alleviating the burden of tuberculosis (TB) requires an understanding of the genetic basis that determines the emergence of drug-resistant mutants. PA-824 (pretomanid) is a bicyclic nitroimidazole class compound presently undergoing the phase III STAND clinical trial, despite lacking identifiable ge...

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Vydáno v:Antimicrob Agents Chemother
Hlavní autoři: Haver, Hana L., Chua, Adeline, Ghode, Pramila, Lakshminarayana, Suresh B., Singhal, Amit, Mathema, Barun, Wintjens, René, Bifani, Pablo
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Microbiology 2015
Témata:
Mechanisms of Resistance
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4538556/
https://ncbi.nlm.nih.gov/pubmed/26100695
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.00308-15
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