Discovery of Tetrahydropyrazolopyrimidine Carboxamide Derivatives As Potent and Orally Active Antitubercular Agents

[Image: see text] Tetrahydropyrazolo[1,5-a]pyrimidine scaffold was identified as a hit series from a Mycobacterium tuberculosis (Mtb) whole cell high through-put screening (HTS) campaign. A series of derivatives of this class were synthesized to evaluate their structure–activity relationship (SAR) a...

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Autors principals: Yokokawa, Fumiaki, Wang, Gang, Chan, Wai Ling, Ang, Shi Hua, Wong, Josephine, Ma, Ida, Rao, Srinivasa P S, Manjunatha, Ujjini, Lakshminarayana, Suresh B, Herve, Maxime, Kounde, Cyrille, Tan, Bee Huat, Thayalan, Pamela, Ng, Seow Hwee, Nanjundappa, Mahesh, Ravindran, Sindhu, Gee, Peck, Tan, Maria, Wei, Liu, Goh, Anne, Chen, Pei-Yu, Lee, Kok Sin, Zhong, Chen, Wagner, Trixie, Dix, Ina, Chatterjee, Arnab K., Pethe, Kevin, Kuhen, Kelli, Glynne, Richard, Smith, Paul, Bifani, Pablo, Jiricek, Jan
Format: Artigo
Idioma:Inglês
Publicat: American Chemical Society 2013
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4027361/
https://ncbi.nlm.nih.gov/pubmed/24900693
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ml400071a
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