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TrkB Inhibition by GNF-4256 Slows Growth and Enhances Chemotherapeutic Efficacy in Neuroblastoma Xenografts

PURPOSE: Neuroblastoma (NB) is one of the most common and deadly pediatric solid tumors. NB is characterized by clinical heterogeneity, from spontaneous regression to relentless progression despite intensive multimodality therapy. There is compelling evidence that members of the tropomyosin receptor...

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Detalhes bibliográficos
Publicado no:Cancer Chemother Pharmacol
Main Authors: Croucher, Jamie L., Iyer, Radhika, Li, Nanxin, Molteni, Valentina, Loren, Jon, Gordon, W. Perry, Tuntland, Tove, Liu, Bo, Brodeur, Garrett M.
Formato: Artigo
Idioma:Inglês
Publicado em: 2014
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4282593/
https://ncbi.nlm.nih.gov/pubmed/25394774
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00280-014-2627-1
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