A carregar...

(R)-2-Phenylpyrrolidine Substituted Imidazopyridazines: A New Class of Potent and Selective Pan-TRK Inhibitors

[Image: see text] Deregulated kinase activities of tropomyosin receptor kinase (TRK) family members have been shown to be associated with tumorigenesis and poor prognosis in a variety of cancer types. In particular, several chromosomal rearrangements involving TRKA have been reported in colorectal,...

ver descrição completa

Na minha lista:
Detalhes bibliográficos
Publicado no:ACS Med Chem Lett
Main Authors: Choi, Ha-Soon, Rucker, Paul V., Wang, Zhicheng, Fan, Yi, Albaugh, Pamela, Chopiuk, Greg, Gessier, Francois, Sun, Fangxian, Adrian, Francisco, Liu, Guoxun, Hood, Tami, Li, Nanxin, Jia, Yong, Che, Jianwei, McCormack, Susan, Li, Allen, Li, Jie, Steffy, Auzon, Culazzo, AnneMarie, Tompkins, Celine, Phung, Van, Kreusch, Andreas, Lu, Min, Hu, Bin, Chaudhary, Apurva, Prashad, Mahavir, Tuntland, Tove, Liu, Bo, Harris, Jennifer, Seidel, H. Martin, Loren, Jon, Molteni, Valentina
Formato: Artigo
Idioma:Inglês
Publicado em: American Chemical Society 2015
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4434478/
https://ncbi.nlm.nih.gov/pubmed/26005534
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acsmedchemlett.5b00050
Tags: Adicionar Tag
Sem tags, seja o primeiro a adicionar uma tag!