(R)-2-Phenylpyrrolidine Substituted Imidazopyridazines: A New Class of Potent and Selective Pan-TRK Inhibitors

[Image: see text] Deregulated kinase activities of tropomyosin receptor kinase (TRK) family members have been shown to be associated with tumorigenesis and poor prognosis in a variety of cancer types. In particular, several chromosomal rearrangements involving TRKA have been reported in colorectal,...

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Опубликовано в: :ACS Med Chem Lett
Главные авторы: Choi, Ha-Soon, Rucker, Paul V., Wang, Zhicheng, Fan, Yi, Albaugh, Pamela, Chopiuk, Greg, Gessier, Francois, Sun, Fangxian, Adrian, Francisco, Liu, Guoxun, Hood, Tami, Li, Nanxin, Jia, Yong, Che, Jianwei, McCormack, Susan, Li, Allen, Li, Jie, Steffy, Auzon, Culazzo, AnneMarie, Tompkins, Celine, Phung, Van, Kreusch, Andreas, Lu, Min, Hu, Bin, Chaudhary, Apurva, Prashad, Mahavir, Tuntland, Tove, Liu, Bo, Harris, Jennifer, Seidel, H. Martin, Loren, Jon, Molteni, Valentina
Формат: Artigo
Язык:Inglês
Опубликовано: American Chemical Society 2015
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC4434478/
https://ncbi.nlm.nih.gov/pubmed/26005534
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acsmedchemlett.5b00050
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