Discovery of BAF312 (Siponimod), a Potent and Selective S1P Receptor Modulator

[Image: see text] A novel series of alkoxyimino derivatives as S1P(1) agonists were discovered through de novo design using FTY720 as the chemical starting point. Extensive structure–activity relationship studies led to the discovery of (E)-1-(4-(1-(((4-cyclohexyl-3-(trifluoromethyl)benzyl)oxy)imino...

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Detaylı Bibliyografya
Asıl Yazarlar: Pan, Shifeng, Gray, Nathanael S., Gao, Wenqi, Mi, Yuan, Fan, Yi, Wang, Xing, Tuntland, Tove, Che, Jianwei, Lefebvre, Sophie, Chen, Yu, Chu, Alan, Hinterding, Klaus, Gardin, Anne, End, Peter, Heining, Peter, Bruns, Christian, Cooke, Nigel G., Nuesslein-Hildesheim, Barbara
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: American Chemical Society 2013
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC4027137/
https://ncbi.nlm.nih.gov/pubmed/24900670
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ml300396r
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