Discovery of BAF312 (Siponimod), a Potent and Selective S1P Receptor Modulator

[Image: see text] A novel series of alkoxyimino derivatives as S1P(1) agonists were discovered through de novo design using FTY720 as the chemical starting point. Extensive structure–activity relationship studies led to the discovery of (E)-1-(4-(1-(((4-cyclohexyl-3-(trifluoromethyl)benzyl)oxy)imino...

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Detalhes bibliográficos
Main Authors: Pan, Shifeng, Gray, Nathanael S., Gao, Wenqi, Mi, Yuan, Fan, Yi, Wang, Xing, Tuntland, Tove, Che, Jianwei, Lefebvre, Sophie, Chen, Yu, Chu, Alan, Hinterding, Klaus, Gardin, Anne, End, Peter, Heining, Peter, Bruns, Christian, Cooke, Nigel G., Nuesslein-Hildesheim, Barbara
Formato: Artigo
Idioma:Inglês
Publicado em: American Chemical Society 2013
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4027137/
https://ncbi.nlm.nih.gov/pubmed/24900670
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ml300396r
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