Discovery of BAF312 (Siponimod), a Potent and Selective S1P Receptor Modulator

[Image: see text] A novel series of alkoxyimino derivatives as S1P(1) agonists were discovered through de novo design using FTY720 as the chemical starting point. Extensive structure–activity relationship studies led to the discovery of (E)-1-(4-(1-(((4-cyclohexyl-3-(trifluoromethyl)benzyl)oxy)imino...

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Hlavní autoři: Pan, Shifeng, Gray, Nathanael S., Gao, Wenqi, Mi, Yuan, Fan, Yi, Wang, Xing, Tuntland, Tove, Che, Jianwei, Lefebvre, Sophie, Chen, Yu, Chu, Alan, Hinterding, Klaus, Gardin, Anne, End, Peter, Heining, Peter, Bruns, Christian, Cooke, Nigel G., Nuesslein-Hildesheim, Barbara
Médium: Artigo
Jazyk:Inglês
Vydáno: American Chemical Society 2013
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4027137/
https://ncbi.nlm.nih.gov/pubmed/24900670
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ml300396r
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