Dose titration of BAF312 attenuates the initial heart rate reducing effect in healthy subjects

AIM: Previous studies have shown transient decreases in heart rate (HR) following administration of sphingosine 1‐phosphate (S1P) receptor modulators including BAF312. This study was conducted to determine whether dose titration of BAF312 reduces or eliminates these effects. METHODS: Fifty‐six healt...

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Bibliographic Details
Main Authors: Legangneux, Eric, Gardin, Anne, Johns, Donald
Format: Artigo
Language:Inglês
Published: Blackwell Publishing Ltd 2013
Subjects:
Drug Safety
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3575950/
https://ncbi.nlm.nih.gov/pubmed/22845008
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1365-2125.2012.04400.x
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