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Dose titration of BAF312 attenuates the initial heart rate reducing effect in healthy subjects

AIM: Previous studies have shown transient decreases in heart rate (HR) following administration of sphingosine 1‐phosphate (S1P) receptor modulators including BAF312. This study was conducted to determine whether dose titration of BAF312 reduces or eliminates these effects. METHODS: Fifty‐six healt...

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Detalhes bibliográficos
Main Authors: Legangneux, Eric, Gardin, Anne, Johns, Donald
Formato: Artigo
Idioma:Inglês
Publicado em: Blackwell Publishing Ltd 2013
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3575950/
https://ncbi.nlm.nih.gov/pubmed/22845008
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1365-2125.2012.04400.x
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