Phase I study of oral sonidegib (LDE225) in pediatric brain and solid tumors and a phase II study in children and adults with relapsed medulloblastoma

BACKGROUND: Sonidegib (LDE225) is a potent, selective hedgehog (Hh) inhibitor of Smoothened. This study explored the safety and pharmacokinetics of sonidegib in children with relapsed/recurrent tumors followed by a phase II trial in pediatric and adult patients with relapsed medulloblastoma (MB) to...

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Bibliografski detalji
Izdano u:Neuro Oncol
Glavni autori: Kieran, Mark W, Chisholm, Julia, Casanova, Michela, Brandes, Alba A, Aerts, Isabelle, Bouffet, Eric, Bailey, Simon, Leary, Sarah, MacDonald, Tobey J, Mechinaud, Francoise, Cohen, Kenneth J, Riccardi, Riccardo, Mason, Warren, Hargrave, Darren, Kalambakas, Stacey, Deshpande, Priya, Tai, Feng, Hurh, Eunju, Geoerger, Birgit
Format: Artigo
Jezik:Inglês
Izdano: Oxford University Press 2017
Teme:
Pediatric Neuro-Oncology
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5737275/
https://ncbi.nlm.nih.gov/pubmed/28605510
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/nox109
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