Pharmacodynamic and pharmacokinetic neoadjuvant study of hedgehog pathway inhibitor Sonidegib (LDE-225) in men with high-risk localized prostate cancer undergoing prostatectomy

PURPOSE: To determine the pharmacodynamic effects of Sonidegib (LDE-225) in prostate tumor tissue from men with high-risk localized prostate cancer, by comparing pre-surgical core-biopsy specimens to tumor tissue harvested post-treatment at prostatectomy. METHODS: We conducted a prospective randomiz...

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Detalhes bibliográficos
Publicado no:Oncotarget
Main Authors: Ross, Ashley E., Hughes, Robert M., Glavaris, Stephanie, Ghabili, Kamyar, He, Ping, Anders, Nicole M., Harb, Rana, Tosoian, Jeffrey J., Marchionni, Luigi, Schaeffer, Edward M., Partin, Alan W., Allaf, Mohamad E., Bivalacqua, Trinity J., Chapman, Carolyn, O’Neal, Tanya, DeMarzo, Angelo M., Hurley, Paula J., Rudek, Michelle A., Antonarakis, Emmanuel S.
Formato: Artigo
Idioma:Inglês
Publicado em: Impact Journals LLC 2017
Assuntos:
Research Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5732797/
https://ncbi.nlm.nih.gov/pubmed/29262631
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.22115
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