Pharmacodynamic and pharmacokinetic neoadjuvant study of hedgehog pathway inhibitor Sonidegib (LDE-225) in men with high-risk localized prostate cancer undergoing prostatectomy

PURPOSE: To determine the pharmacodynamic effects of Sonidegib (LDE-225) in prostate tumor tissue from men with high-risk localized prostate cancer, by comparing pre-surgical core-biopsy specimens to tumor tissue harvested post-treatment at prostatectomy. METHODS: We conducted a prospective randomiz...

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Kaydedildi:
Detaylı Bibliyografya
Yayımlandı:Oncotarget
Asıl Yazarlar: Ross, Ashley E., Hughes, Robert M., Glavaris, Stephanie, Ghabili, Kamyar, He, Ping, Anders, Nicole M., Harb, Rana, Tosoian, Jeffrey J., Marchionni, Luigi, Schaeffer, Edward M., Partin, Alan W., Allaf, Mohamad E., Bivalacqua, Trinity J., Chapman, Carolyn, O’Neal, Tanya, DeMarzo, Angelo M., Hurley, Paula J., Rudek, Michelle A., Antonarakis, Emmanuel S.
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: Impact Journals LLC 2017
Konular:
Research Paper
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC5732797/
https://ncbi.nlm.nih.gov/pubmed/29262631
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.22115
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