Pharmacodynamic and pharmacokinetic neoadjuvant study of hedgehog pathway inhibitor Sonidegib (LDE-225) in men with high-risk localized prostate cancer undergoing prostatectomy

PURPOSE: To determine the pharmacodynamic effects of Sonidegib (LDE-225) in prostate tumor tissue from men with high-risk localized prostate cancer, by comparing pre-surgical core-biopsy specimens to tumor tissue harvested post-treatment at prostatectomy. METHODS: We conducted a prospective randomiz...

Fuld beskrivelse

Na minha lista:
Bibliografiske detaljer
Udgivet i:Oncotarget
Main Authors: Ross, Ashley E., Hughes, Robert M., Glavaris, Stephanie, Ghabili, Kamyar, He, Ping, Anders, Nicole M., Harb, Rana, Tosoian, Jeffrey J., Marchionni, Luigi, Schaeffer, Edward M., Partin, Alan W., Allaf, Mohamad E., Bivalacqua, Trinity J., Chapman, Carolyn, O’Neal, Tanya, DeMarzo, Angelo M., Hurley, Paula J., Rudek, Michelle A., Antonarakis, Emmanuel S.
Format: Artigo
Sprog:Inglês
Udgivet: Impact Journals LLC 2017
Fag:
Research Paper
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5732797/
https://ncbi.nlm.nih.gov/pubmed/29262631
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.22115
Tags: Tilføj Tag
Ingen Tags, Vær først til at tagge denne postø!

Lignende værker