Hedgehog pathway blockade with the cancer drug LDE225 disrupts taste organs and taste sensation

Taste sensation on the anterior tongue requires chorda tympani nerve function and connections with continuously renewing taste receptor cells. However, it is unclear which signaling pathways regulate the receptor cells to maintain chorda tympani sensation. Hedgehog (HH) signaling controls cell proli...

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Detalles Bibliográficos
Publicado en:J Neurophysiol
Autores principales: Kumari, Archana, Ermilov, Alexandre N., Allen, Benjamin L., Bradley, Robert M., Dlugosz, Andrzej A., Mistretta, Charlotte M.
Formato: Artigo
Lenguaje:Inglês
Publicado: American Physiological Society 2014
Materias:
Rapid Report
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC4312875/
https://ncbi.nlm.nih.gov/pubmed/25392175
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/jn.00822.2014
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