Chronic myeloid leukaemia cells require the bone morphogenic protein pathway for cell cycle progression and self-renewal

Leukaemic stem cell (LSC) persistence remains a major obstacle to curing chronic myeloid leukaemia (CML). The bone morphogenic protein (BMP) pathway is deregulated in CML, with altered expression and response to the BMP ligands shown to impact on LSC expansion and behaviour. In this study, we determ...

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Detalhes bibliográficos
Publicado no:Cell Death Dis
Main Authors: Toofan, Parto, Busch, Caroline, Morrison, Heather, O’Brien, Stephen, Jørgensen, Heather, Copland, Mhairi, Wheadon, Helen
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2018
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6134087/
https://ncbi.nlm.nih.gov/pubmed/30206237
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41419-018-0905-2
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