Chronic myeloid leukaemia cells require the bone morphogenic protein pathway for cell cycle progression and self-renewal

Leukaemic stem cell (LSC) persistence remains a major obstacle to curing chronic myeloid leukaemia (CML). The bone morphogenic protein (BMP) pathway is deregulated in CML, with altered expression and response to the BMP ligands shown to impact on LSC expansion and behaviour. In this study, we determ...

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Pubblicato in:Cell Death Dis
Autori principali: Toofan, Parto, Busch, Caroline, Morrison, Heather, O’Brien, Stephen, Jørgensen, Heather, Copland, Mhairi, Wheadon, Helen
Natura: Artigo
Lingua:Inglês
Pubblicazione: Nature Publishing Group UK 2018
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6134087/
https://ncbi.nlm.nih.gov/pubmed/30206237
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41419-018-0905-2
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