Dual targeting of p53 and c-Myc selectively eliminates leukaemic stem cells

Chronic myeloid leukaemia (CML) arises following transformation of a haemopoietic stem cell (HSC) by protein-tyrosine kinase BCR-ABL1. Direct inhibition of BCR-ABL1 kinase has revolutionized disease management, but fails to eradicate leukaemic stem cells (LSC), which maintain CML. LSC are independen...

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Publicado no:Nature
Main Authors: Abraham, Sheela A, Hopcroft, Lisa EM, Carrick, Emma, Drotar, Mark E, Dunn, Karen, Williamson, Andrew JK, Korfi, Koorosh, Baquero, Pablo, Park, Laura E, Scott, Mary T, Pellicano, Francesca, Pierce, Andrew, Copland, Mhairi, Nourse, Craig, Grimmond, Sean M, Vetrie, David, Whetton, Anthony D, Holyoake, Tessa L
Formato: Artigo
Idioma:Inglês
Publicado em: 2016
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4913876/
https://ncbi.nlm.nih.gov/pubmed/27281222
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nature18288
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