Dual targeting of p53 and c-Myc selectively eliminates leukaemic stem cells

Chronic myeloid leukaemia (CML) arises following transformation of a haemopoietic stem cell (HSC) by protein-tyrosine kinase BCR-ABL1. Direct inhibition of BCR-ABL1 kinase has revolutionized disease management, but fails to eradicate leukaemic stem cells (LSC), which maintain CML. LSC are independen...

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Gepubliceerd in:Nature
Hoofdauteurs: Abraham, Sheela A, Hopcroft, Lisa EM, Carrick, Emma, Drotar, Mark E, Dunn, Karen, Williamson, Andrew JK, Korfi, Koorosh, Baquero, Pablo, Park, Laura E, Scott, Mary T, Pellicano, Francesca, Pierce, Andrew, Copland, Mhairi, Nourse, Craig, Grimmond, Sean M, Vetrie, David, Whetton, Anthony D, Holyoake, Tessa L
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: 2016
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Article
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4913876/
https://ncbi.nlm.nih.gov/pubmed/27281222
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nature18288
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