Defective nonhomologous end joining blocks B-cell development in FLT3/ITD mice

We have generated an FLT3/ITD knock-in mouse model in which mice with an FLT3/ITD mutation develop myeloproliferative disease (MPD) and a block in early B-lymphocyte development. To elucidate the role of FLT3/ITD signaling in B-cell development, we studied VDJ recombination in the pro-B cells of FLT...

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Detalhes bibliográficos
Main Authors: Li, Li, Zhang, Li, Fan, Jinshui, Greenberg, Kathleen, Desiderio, Stephen, Rassool, Feyruz V., Small, Donald
Formato: Artigo
Idioma:Inglês
Publicado em: American Society of Hematology 2011
Assuntos:
Lymphoid Neoplasia
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3062315/
https://ncbi.nlm.nih.gov/pubmed/21228325
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2010-05-286070
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