Fluvastatin inhibits FLT3 glycosylation in human and murine cells and prolongs survival of mice with FLT3/ITD leukemia

FLT3 is frequently mutated in acute myeloid leukemia (AML), but resistance has limited the benefit of tyrosine kinase inhibitors (TKI). We demonstrate that statins can impair FLT3 glycosylation, thus leading to loss of surface expression and induction of cell death, as well as mitigation of TKI resi...

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Detalhes bibliográficos
Main Authors: Williams, Allen B., Li, Li, Nguyen, Bao, Brown, Patrick, Levis, Mark, Small, Donald
Formato: Artigo
Idioma:Inglês
Publicado em: American Society of Hematology 2012
Assuntos:
Myeloid Neoplasia
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3471516/
https://ncbi.nlm.nih.gov/pubmed/22927251
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2012-01-403493
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