All-trans retinoic acid synergizes with FLT3 inhibition to eliminate FLT3/ITD(+) leukemia stem cells in vitro and in vivo

FMS-like tyrosine kinase 3 (FLT3)-mutant acute myeloid leukemia (AML) portends a poor prognosis, and ineffective targeting of the leukemic stem cell (LSC) population remains one of several obstacles in treating this disease. All-trans retinoic acid (ATRA) has been used in several clinical trials for...

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Detaylı Bibliyografya
Yayımlandı:Blood
Asıl Yazarlar: Ma, Hayley S., Greenblatt, Sarah M., Shirley, Courtney M., Duffield, Amy S., Bruner, J. Kyle, Li, Li, Nguyen, Bao, Jung, Eric, Aplan, Peter D., Ghiaur, Gabriel, Jones, Richard J., Small, Donald
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: American Society of Hematology 2016
Konular:
Myeloid Neoplasia
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC4900954/
https://ncbi.nlm.nih.gov/pubmed/27103744
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2015-05-646786
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