All-trans retinoic acid synergizes with FLT3 inhibition to eliminate FLT3/ITD(+) leukemia stem cells in vitro and in vivo

FMS-like tyrosine kinase 3 (FLT3)-mutant acute myeloid leukemia (AML) portends a poor prognosis, and ineffective targeting of the leukemic stem cell (LSC) population remains one of several obstacles in treating this disease. All-trans retinoic acid (ATRA) has been used in several clinical trials for...

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Enregistré dans:
Détails bibliographiques
Publié dans:Blood
Auteurs principaux: Ma, Hayley S., Greenblatt, Sarah M., Shirley, Courtney M., Duffield, Amy S., Bruner, J. Kyle, Li, Li, Nguyen, Bao, Jung, Eric, Aplan, Peter D., Ghiaur, Gabriel, Jones, Richard J., Small, Donald
Format: Artigo
Langue:Inglês
Publié: American Society of Hematology 2016
Sujets:
Myeloid Neoplasia
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4900954/
https://ncbi.nlm.nih.gov/pubmed/27103744
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2015-05-646786
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