All-trans retinoic acid synergizes with FLT3 inhibition to eliminate FLT3/ITD(+) leukemia stem cells in vitro and in vivo

FMS-like tyrosine kinase 3 (FLT3)-mutant acute myeloid leukemia (AML) portends a poor prognosis, and ineffective targeting of the leukemic stem cell (LSC) population remains one of several obstacles in treating this disease. All-trans retinoic acid (ATRA) has been used in several clinical trials for...

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Publicado en:Blood
Main Authors: Ma, Hayley S., Greenblatt, Sarah M., Shirley, Courtney M., Duffield, Amy S., Bruner, J. Kyle, Li, Li, Nguyen, Bao, Jung, Eric, Aplan, Peter D., Ghiaur, Gabriel, Jones, Richard J., Small, Donald
Formato: Artigo
Idioma:Inglês
Publicado: American Society of Hematology 2016
Assuntos:
Myeloid Neoplasia
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC4900954/
https://ncbi.nlm.nih.gov/pubmed/27103744
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2015-05-646786
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