Retinoic acid synergizes with the unfolded protein response and oxidative stress to induce cell death in FLT3-ITD(+) AML

Acute myeloid leukemia (AML) is often characterized by the expression of fusion or mutant proteins that cause impaired differentiation and enhanced proliferation and survival. The presence of mutant proteins prone to misfolding can render the cells sensitive to endoplasmic reticulum (ER) stress and...

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Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Blood Adv
Prif Awduron: Masciarelli, Silvia, Capuano, Ernestina, Ottone, Tiziana, Divona, Mariadomenica, Lavorgna, Serena, Liccardo, Francesca, Śniegocka, Martyna, Travaglini, Serena, Noguera, Nelida I., Picardi, Alessandra, Petrozza, Vincenzo, Fatica, Alessandro, Tamagnone, Luca, Voso, Maria Teresa, Lo Coco, Francesco, Fazi, Francesco
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: American Society of Hematology 2019
Pynciau:
Myeloid Neoplasia
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC6929380/
https://ncbi.nlm.nih.gov/pubmed/31834935
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/bloodadvances.2019000540
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