Retinoic acid and arsenic trioxide sensitize acute promyelocytic leukemia cells to ER stress

Retinoic acid (RA) in association with chemotherapy or with arsenic trioxide (ATO) results in high cure rates of acute promyelocytic leukemia (APL). We show that RA-induced differentiation of human leukemic cell lines and primary blasts dramatically increases their sensitivity to endoplasmic reticul...

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Bibliografiske detaljer
Udgivet i:Leukemia
Main Authors: Masciarelli, S, Capuano, E, Ottone, T, Divona, M, De Panfilis, S, Banella, C, Noguera, N I, Picardi, A, Fontemaggi, G, Blandino, G, Lo-Coco, F, Fazi, F
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group 2018
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Original Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5808088/
https://ncbi.nlm.nih.gov/pubmed/28776567
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/leu.2017.231
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