Fluvastatin inhibits FLT3 glycosylation in human and murine cells and prolongs survival of mice with FLT3/ITD leukemia

FLT3 is frequently mutated in acute myeloid leukemia (AML), but resistance has limited the benefit of tyrosine kinase inhibitors (TKI). We demonstrate that statins can impair FLT3 glycosylation, thus leading to loss of surface expression and induction of cell death, as well as mitigation of TKI resi...

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Bibliografiske detaljer
Main Authors: Williams, Allen B., Li, Li, Nguyen, Bao, Brown, Patrick, Levis, Mark, Small, Donald
Format: Artigo
Sprog:Inglês
Udgivet: American Society of Hematology 2012
Fag:
Myeloid Neoplasia
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3471516/
https://ncbi.nlm.nih.gov/pubmed/22927251
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2012-01-403493
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