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FLT3-ITD impedes retinoic acid, but not arsenic, responses in murine acute promyelocytic leukemias
Acute promyelocytic leukemia (APL) is often associated with activating FLT3 signaling mutations. These are highly related to hyperleukocytosis, a major adverse risk factor with chemotherapy-based regimens. APL is a model for oncogene-targeted therapies: all-trans retinoic acid (ATRA) and arsenic bot...
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| Publicado no: | Blood |
|---|---|
| Main Authors: | , , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
American Society of Hematology
2019
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6440296/ https://ncbi.nlm.nih.gov/pubmed/30674471 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2018-07-866095 |
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