FLT3-ITD impedes retinoic acid, but not arsenic, responses in murine acute promyelocytic leukemias

Acute promyelocytic leukemia (APL) is often associated with activating FLT3 signaling mutations. These are highly related to hyperleukocytosis, a major adverse risk factor with chemotherapy-based regimens. APL is a model for oncogene-targeted therapies: all-trans retinoic acid (ATRA) and arsenic bot...

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Publicat a:Blood
Autors principals: Esnault, Cécile, Rahmé, Ramy, Rice, Kim L., Berthier, Caroline, Gaillard, Coline, Quentin, Samuel, Maubert, Anne-Lise, Kogan, Scott, de Thé, Hugues
Format: Artigo
Idioma:Inglês
Publicat: American Society of Hematology 2019
Matèries:
Myeloid Neoplasia
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6440296/
https://ncbi.nlm.nih.gov/pubmed/30674471
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2018-07-866095
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