FLT3-ITD impedes retinoic acid, but not arsenic, responses in murine acute promyelocytic leukemias

Acute promyelocytic leukemia (APL) is often associated with activating FLT3 signaling mutations. These are highly related to hyperleukocytosis, a major adverse risk factor with chemotherapy-based regimens. APL is a model for oncogene-targeted therapies: all-trans retinoic acid (ATRA) and arsenic bot...

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Bibliographische Detailangaben
Veröffentlicht in:Blood
Hauptverfasser: Esnault, Cécile, Rahmé, Ramy, Rice, Kim L., Berthier, Caroline, Gaillard, Coline, Quentin, Samuel, Maubert, Anne-Lise, Kogan, Scott, de Thé, Hugues
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society of Hematology 2019
Schlagworte:
Myeloid Neoplasia
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6440296/
https://ncbi.nlm.nih.gov/pubmed/30674471
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2018-07-866095
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