FLT3-ITD impedes retinoic acid, but not arsenic, responses in murine acute promyelocytic leukemias

Acute promyelocytic leukemia (APL) is often associated with activating FLT3 signaling mutations. These are highly related to hyperleukocytosis, a major adverse risk factor with chemotherapy-based regimens. APL is a model for oncogene-targeted therapies: all-trans retinoic acid (ATRA) and arsenic bot...

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Udgivet i:Blood
Main Authors: Esnault, Cécile, Rahmé, Ramy, Rice, Kim L., Berthier, Caroline, Gaillard, Coline, Quentin, Samuel, Maubert, Anne-Lise, Kogan, Scott, de Thé, Hugues
Format: Artigo
Sprog:Inglês
Udgivet: American Society of Hematology 2019
Fag:
Myeloid Neoplasia
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6440296/
https://ncbi.nlm.nih.gov/pubmed/30674471
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2018-07-866095
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