FLT3-ITD impedes retinoic acid, but not arsenic, responses in murine acute promyelocytic leukemias

Acute promyelocytic leukemia (APL) is often associated with activating FLT3 signaling mutations. These are highly related to hyperleukocytosis, a major adverse risk factor with chemotherapy-based regimens. APL is a model for oncogene-targeted therapies: all-trans retinoic acid (ATRA) and arsenic bot...

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Bibliografische gegevens
Gepubliceerd in:Blood
Hoofdauteurs: Esnault, Cécile, Rahmé, Ramy, Rice, Kim L., Berthier, Caroline, Gaillard, Coline, Quentin, Samuel, Maubert, Anne-Lise, Kogan, Scott, de Thé, Hugues
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: American Society of Hematology 2019
Onderwerpen:
Myeloid Neoplasia
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6440296/
https://ncbi.nlm.nih.gov/pubmed/30674471
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2018-07-866095
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