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Partnering with PARP inhibitors in acute myeloid leukemia with FLT3-ITD
Internal tandem duplications within the juxtamembrane domain of fms-like tyrosine kinase 3 (FLT3-ITD) occur in acute myeloid leukemia (AML) cells of 20-25% of patients and are associated with poor treatment outcomes. FLT3 inhibitors have been developed, but have had limited clinical efficacy due to...
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| Publicado no: | Cancer Lett |
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| Main Authors: | , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2019
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6528833/ https://ncbi.nlm.nih.gov/pubmed/30953707 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.canlet.2019.03.048 |
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