Up-regulation of WRN and DNA ligase IIIα in chronic myeloid leukemia: consequences for the repair of DNA double-strand breaks

Expression of oncogenic BCR-ABL in chronic myeloid leukemia (CML) results in increased reactive oxygen species (ROS) that in turn cause increased DNA damage, including DNA double-strand breaks (DSBs). We have previously shown increased error-prone repair of DSBs by nonhomologous end-joining (NHEJ) i...

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Bibliographic Details
Main Authors: Sallmyr, Annahita, Tomkinson, Alan E., Rassool, Feyruz V.
Format: Artigo
Language:Inglês
Published: American Society of Hematology 2008
Subjects:
Neoplasia
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2967309/
https://ncbi.nlm.nih.gov/pubmed/18524993
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2007-07-104257
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